Research
Hormonal
Parathyroid hormone (PTH) mediates the relationship between low Vitamin D and non-energy-expenditure aspects of frailty (slowness, weakness) in men.
For older men with low Vitamin D, high PTH levels might be the actual cause of muscle weakness and slowness. Doctors should check PTH levels, not just Vitamin D, to understand frailty risk.
GoodSupportsMEDIUM confidence
Results suggest that PTH mediates the relationship between 25(OH)D and nonenergy expenditure aspects of frailty.
Why this rating
Strong statistical attenuation of OR when controlling for PTH supports mediation, though causality is cross-sectional.
Source
Association of Low Vitamin D Levels With the Frailty Syndrome in Men and Women
Michelle Shardell et al. · The Journals of Gerontology Series A · 2009
DOI 10.1093/gerona/gln007
cross_sectional · n=1005Cited 170×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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