Research
Macro partitioning
The splicing factor SFA-1 (SF1 homolog) promotes longevity in C. elegans, and its depletion compromises the longevity benefits of caloric restriction.
Caloric restriction remains a key longevity strategy; its mechanism may involve splicing factors like SF1 homologs.
ModerateSupportsMEDIUM confidence
overexpression of SFA-1 is sufficient to increase worm longevity. The enhanced longevity elicited by caloric restriction is compromised by depleting SFA-1
Why this rating
Based on worm studies (Heintz et al., 2016); human relevance is not explicitly detailed.
Source
The emerging role of alternative splicing in senescence and aging
Mathieu Deschênes et al. · Aging Cell · 2017
DOI 10.1111/acel.12646
narrative_reviewCited 169×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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