Research
Hormonal
The splicing shift toward ING1a over ING1b promotes cellular senescence and prevents apoptosis, contributing to the maintenance of the senescent state.
No direct human intervention recommended.
ModerateSupportsMEDIUM confidence
The level of ING1a increases at the expense of ING1b when cells approach senescence... cells overexpressing ING1a display senescence phenotypes... The splicing shift toward ING1a may help to maintain the senescence status and thus may prevent apoptosis.
Why this rating
Based on in vitro cell studies (Soliman et al., 2008; Li et al., 2011).
Source
The emerging role of alternative splicing in senescence and aging
Mathieu Deschênes et al. · Aging Cell · 2017
DOI 10.1111/acel.12646
narrative_reviewCited 169×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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