Mixed
Combining protein supplementation (3-40g/day of amino acids/protein) with exercise training significantly increases muscle mass, muscle strength, and functional mobility while reducing pain in older adults with lower-extremity osteoarthritis, particularly those who have undergone total joint replacement.
If you are an older adult with knee or hip osteoarthritis, especially after joint replacement surgery, combining resistance or multicomponent exercise with protein supplementation (3-40g/day of amino acids or protein) is highly effective. This combination significantly increases muscle mass, improves strength, enhances mobility (walking, stair climbing), and reduces pain more than exercise alone. Aim for 2-7 weeks of consistent training with daily protein support to see these benefits.
The PS + ET group exhibited significant improvements in muscle mass (standard mean difference [SMD] = 1.13, p < 0.00001), pain (SMD = 1.36, p < 0.00001), and muscle strength (SMD = 0.44, p = 0.04).
Why this rating
Meta-analysis of 6 RCTs with high methodological quality (median PEDro score 7), though heterogeneity was present in some outcomes.
Source
Effects of Protein Supplementation Combined with Exercise Training on Muscle Mass and Function in Older Adults with Lower-Extremity Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Trials
Chun‐De Liao et al. · Nutrients · 2020
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