Research
Energy balance
Mitochondrial ROS production rates correlate with species-specific aging rates, and targeted mitochondrial catalase expression significantly extends median and maximum lifespan in mice.
Focus on mitochondrial health through exercise and caloric restriction, which naturally reduce ROS production and extend lifespan in models. Do not rely on untargeted antioxidant supplements, as evidence for their efficacy in extending lifespan is lacking or contradictory.
GoodSupportsHIGH confidence
A large body of literature shows that mitochondrial superoxide production rates correlate with rates of ageing in different species... Direct evidence for the relevance of mitochondrial ROS production for mammalian ageing is provided by knock-in mouse models... Only the expression of catalase targeted to mitochondria (MCAT-mice) resulted in decreases in levels of oxidative damage and caused a highly significant increase in both median and maximum lifespan (up to 21%)
Why this rating
Strong correlative data across species and direct causal evidence in transgenic mouse models (MCAT), though human applicability is not directly tested.
Source
The mitochondrial free radical theory of ageing - Where do we stand?
Jan Gruber · Frontiers in bioscience · 2008
DOI 10.2741/3174
narrative_reviewCited 168×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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