Research
Energy balance
Caloric restriction and intermittent fasting extend lifespan and protect tissues through hormetic mechanisms that increase cellular stress resistance.
Consider reducing overall caloric intake or practicing intermittent fasting. The paper suggests this triggers hormetic mechanisms that boost cellular stress resistance and may extend lifespan, countering the negative effects of excessive calorie consumption.
GoodSupportsHIGH confidence
Reducing energy consumption by controlled caloric restriction or intermittent fasting increases lifespan and protects various tissues against diseases, in part, by hormetic mechanisms that increase cellular stress resistance.
Why this rating
The paper cites established toxicology/pharmacology principles of hormesis and broad epidemiological/animal data supporting lifespan extension.
Source
The Hormetic Role of Dietary Antioxidants in Free Radical-Related Diseases
Vittorio Calabrese et al. · Current Pharmaceutical Design · 2010
DOI 10.2174/138161210790883615
narrative_reviewCited 168×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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