Energy balance
Weight loss of 7-10% is required to resolve NAFLD, but achieving this through lifestyle changes alone is difficult as only 10-20% of individuals succeed, and weight loss is less effective for NASH resolution in diabetic patients.
To resolve fatty liver disease, you need to lose 7-10% of your body weight. This is a high bar, and most people struggle to reach it with diet and exercise alone. If you have diabetes, this is even harder. Because lifestyle changes alone often fail to hit this target, you should discuss pharmacological options (like GLP-1 agonists) with your doctor to help you reach this weight loss goal.
A 7% to 10% decrease in body weight is thought to be required for resolution of NAFLD in patients with obesity; however, only 10% to 20% of individuals are able to achieve a weight loss of ≥10% with lifestyle change over 1 to 2 years. It should be underlined that similar weight loss is less effective in reaching NASH resolution in people with diabetes compared with those without diabetes.
Why this rating
Based on a literature review of multiple observational studies and trials.
Source
<scp>Nonalcoholic fatty liver disease</scp> as a metabolic disease in humans: A literature review
Bertrand Cariou et al. · Diabetes Obesity and Metabolism · 2021
DOI 10.1111/dom.14322
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- Lean individuals can develop NAFLD due to visceral adiposity and insulin resistance, and this condition carries similar risks of fibrosis and NASH as obesity-related NAFLD.Good
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