Research
Hormonal
Dysbiosis and increased gut permeability (leaky gut) contribute to obesity through metabolic endotoxemia and low-grade inflammation.
Focus on reducing inflammation through a balanced diet rich in anti-inflammatory foods. Addressing gut health may help manage obesity-related inflammation.
ModerateSupportsMEDIUM confidence
Obesity can be characterized by low-grade inflammation; however, the role of triggering factors and the immune system is still being debated.
Why this rating
The paper reviews studies linking LPS and inflammation to obesity, but notes the causal relationship is still debated.
Source
Gut Microbiota: From Microorganisms to Metabolic Organ Influencing Obesity
Richard W. Stephens et al. · Obesity · 2018
DOI 10.1002/oby.22179
narrative_reviewCited 167×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Gut microbiota composition influences obesity risk through energy harvesting efficiency, specifically via the Firmicutes-to-Bacteroidetes ratio and short-chain fatty acid (SCFA) production.Moderate
- Short-chain fatty acids (SCFAs) produced by gut microbiota influence host energy homeostasis and adipose storage through multiple mechanisms including GPCR signaling and histone deacetylase inhibition.Moderate
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