Research

Micronutrients & recovery

Higher plasma levels of the dietary metabolite ergothioneine are independently associated with a reduced risk of coronary artery disease, cardiovascular mortality, and all-cause mortality.

Focus on a healthy dietary pattern that includes foods rich in ergothioneine, such as mushrooms, garlic, and certain grains. This study suggests that maintaining higher levels of this specific metabolite through diet is associated with a lower risk of heart disease and death, independent of other risk factors like cholesterol and blood pressure.

ModerateSupportsMEDIUM confidence
Ergothioneine was the metabolite most strongly connected to the hcFP and was associated with a lower risk of coronary disease (hr per 1 sD increment of ergothioneine, hr=0.85, p=0.01), cardiovascular mortality (hr=0.79, p=0.002) and overall mortality (hr=0.86, p=4e-5).
Einar Smith et al. · Heart · 2019

Why this rating

Observational cohort study with long follow-up and robust adjustment, but causality is not proven.

Source

Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease

Einar Smith et al. · Heart · 2019

cohort · n=3236Cited 167×
Read the paper

This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →