Research
Hormonal
The cognitive benefits of weight loss are stronger in younger seniors (under 70) for memory/fluency and in APOE4 carriers for executive function.
Older adults with MCI who are closer to 60 years old or who carry the APOE4 gene variant may see greater cognitive improvements from weight loss compared to those over 70 or non-carriers.
GoodQualifiesHIGH confidence
this association was strongest in younger seniors (for memory and fluency) and in APOE4 carriers (for executive function).
Why this rating
Statistically significant interactions found in the pooled analysis.
Source
Cognitive Effects of Intentional Weight Loss in Elderly Obese Individuals With Mild Cognitive Impairment
Nídia Celeste Horie et al. · The Journal of Clinical Endocrinology & Metabolism · 2015
DOI 10.1210/jc.2015-2315
rct · n=80Cited 166×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Intentional weight loss via caloric restriction in obese elderly individuals with mild cognitive impairment (MCI) is associated with improvements in global cognition, verbal memory, executive function, and language.Good
- Reductions in insulin resistance (HOMA-IR), inflammation (CRP), and caloric/macronutrient intake are associated with cognitive improvements in MCI patients.Good
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