Research
Hormonal
SGLT2 inhibitors reduce oxidative stress and inflammation in cardiac tissue by improving nitric oxide bioavailability, stimulating Nrf2/ARE signaling, and suppressing NADPH oxidase.
SGLT2 inhibitors help protect heart cells from damage caused by oxidative stress and inflammation, which contributes to their ability to prevent heart failure.
GoodSupportsHIGH confidence
SGLT2i had cytoprotective properties in endothelial cells; indeed, both empagliflozin and dapagliflozin restored NO bioavailability by inhibiting ROS generation... SGLT2i can prevent cardiac dysfunction by improving oxidative stress... via the stimulation of Nrf2/ARE signaling and suppression of the TGF-β/Smad pathway.
Why this rating
Supported by in vitro, animal, and clinical studies cited in the review.
Source
Anti-Inflammation and Anti-Oxidation: The Key to Unlocking the Cardiovascular Potential of SGLT2 Inhibitors and GLP1 Receptor Agonists
Veronika A. Myasoedova et al. · Antioxidants · 2023
DOI 10.3390/antiox13010016
narrative_reviewCited 31×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- SGLT2 inhibitors and GLP-1 receptor agonists reduce major cardiovascular events and improve cardiac structure/function through anti-inflammatory, anti-oxidative, and metabolic mechanisms, independent of glucose lowering.Good
- SGLT2 inhibitors reduce the incidence of atrial fibrillation (AF) and atrial flutter (AFL) by reducing atrial dilation, intracellular sodium/calcium levels, and epicardial adipose tissue.Good
- GLP-1 receptor agonists reduce stroke risk but do not significantly prevent the onset of atrial fibrillation or atrial flutter, and may increase heart rate.Good
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