Research
Hormonal
GLP-1 receptor agonists reduce stroke risk but do not significantly prevent the onset of atrial fibrillation or atrial flutter, and may increase heart rate.
GLP-1 RAs are effective at reducing stroke risk, but unlike SGLT2 inhibitors, they do not appear to prevent atrial fibrillation and may slightly increase heart rate.
GoodQualifiesHIGH confidence
SGLT2i showed the strongest protection against incident AF/AFL while not improving stroke outcomes. On the other hand, GLP1-RA have demonstrated a reduction in stroke but does not significantly prevent the onset of AF/AFL... GLP1-RA increased the heart rate and the number of adverse cardiac events.
Why this rating
Cited from clinical trials and meta-analyses.
Source
Anti-Inflammation and Anti-Oxidation: The Key to Unlocking the Cardiovascular Potential of SGLT2 Inhibitors and GLP1 Receptor Agonists
Veronika A. Myasoedova et al. · Antioxidants · 2023
DOI 10.3390/antiox13010016
narrative_reviewCited 31×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- SGLT2 inhibitors and GLP-1 receptor agonists reduce major cardiovascular events and improve cardiac structure/function through anti-inflammatory, anti-oxidative, and metabolic mechanisms, independent of glucose lowering.Good
- SGLT2 inhibitors reduce oxidative stress and inflammation in cardiac tissue by improving nitric oxide bioavailability, stimulating Nrf2/ARE signaling, and suppressing NADPH oxidase.Good
- SGLT2 inhibitors reduce the incidence of atrial fibrillation (AF) and atrial flutter (AFL) by reducing atrial dilation, intracellular sodium/calcium levels, and epicardial adipose tissue.Good
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