Mixed
In overweight or obese adults with diabetes, unintentional or general weight loss is associated with a statistically significant increase in all-cause and cardiovascular disease mortality compared to weight stability.
If you have diabetes and are overweight or obese, do not pursue weight loss unless it is explicitly intentional and monitored, as general weight loss is linked to higher mortality in this group. Focus instead on glycemic control and avoiding muscle loss. Consult your endocrinologist before attempting any weight reduction strategy.
We found that compared with a stable weight, weight loss was associated with an increased risk of all-cause mortality (RR, 1.15; 95% CI, 1.04 to 1.28) and cardiovascular disease (CVD) mortality (RR, 1.15; 95% CI, 1.02 to 1.29) in overweight or obese adults with diabetes
Why this rating
Meta-analysis of 8 prospective cohort studies with 18,887 patients; high quality studies (NOS >=7), but observational design limits causal inference.
Source
Weight loss increases all-cause mortality in overweight or obese patients with diabetes
Yiqi Chen et al. · Medicine · 2018
DOI 10.1097/md.0000000000012075
More from this paper
- In overweight or obese diabetic patients, higher initial BMI (specifically >35 kg/m2 and >40 kg/m2) is associated with a dose-dependent increase in all-cause mortality.Good
- Intentional weight loss in overweight or obese diabetic patients is not associated with a significant change in all-cause mortality compared to weight stability.Moderate
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
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- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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