Mixed
In patients with incident cardiovascular disease, increasing the number of metabolic risk factors (hypertension, dyslipidemia, diabetes) is associated with increased risk of subsequent non-fatal coronary heart disease (CHD) and incident heart failure (HF), regardless of BMI.
While having extra weight might help you survive a heart event, having high blood pressure, high cholesterol, or diabetes makes it much more likely you will have another heart attack or develop heart failure. You must manage these metabolic risk factors aggressively, regardless of your weight.
In contrast, the risk of subsequent non-fatal CHD events and incident HF increased with higher BMI and with incremental metabolic risk factors within each BMI category.
Why this rating
Large cohort, robust statistical adjustment, clear dose-response relationship for metabolic factors.
Source
Obesity, metabolic health and clinical outcomes after incident cardiovascular disease: A nationwide population‐based cohort study
Ralph Kwame Akyea et al. · Journal of Cachexia Sarcopenia and Muscle · 2023
DOI 10.1002/jcsm.13340
Related findings · Mixed
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- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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