Hormonal
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) reduce the risk of major adverse cardiovascular events (MACE) by approximately 14% in patients with type 2 diabetes, independent of glucose-lowering effects.
If you have Type 2 Diabetes and are at risk for heart disease, GLP-1 medications (like semaglutide or liraglutide) are proven to significantly lower your risk of heart attack, stroke, and cardiovascular death. These benefits exist even beyond just lowering blood sugar. While injections can cause stomach upset, starting with a low dose and increasing slowly usually manages this. Oral options are also available for some drugs.
Strong evidence of a cardiovascular risk reduction benefit of GLP- 1 RAs in people with T2D has accumulated with data from large cardiovascular outcomes trials (CVOT) collectively showing a significant relative risk reduction of 14% for the 3-component MACE composite outcome (major cardiovascular adverse events, comprising cardiovascular death, myocardial infarction, and non- fatal stroke) (Sattar et al., 2021).
Why this rating
Based on large cardiovascular outcomes trials (CVOT) and systematic reviews/meta-analyses of randomized trials.
Source
Glucagon‐like peptide‐1 receptor agonists to expand the healthy lifespan: Current and future potentials
Frederik Flindt Kreiner et al. · Aging Cell · 2023
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