Research
Energy balance
Weight loss of >10% body weight is required to resolve NASH and regress fibrosis, but this is rarely achieved in routine clinical settings.
Aim for >10% weight loss to potentially reverse NASH and fibrosis, but recognize this is difficult. If you cannot achieve this, focus on a Mediterranean diet to improve liver health and insulin sensitivity even without significant weight loss.
StrongQualifiesHIGH confidence
weight loss of more than 10% of the initial body weight led to a resolution of NASH in 90% of cases, and a regression of fibrosis in 45% of cases... Unfortunately, only 10% of all intensively guided participants could reach this endpoint.
Why this rating
Based on seminal RCTs and bariatric surgery data.
Source
Beyond the Paradigm of Weight Loss in Non-Alcoholic Fatty Liver Disease: From Pathophysiology to Novel Dietary Approaches
Angelo Armandi et al. · Nutrients · 2021
narrative_reviewCited 25×
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