Lifestyle interventions remain critical for optimizing body composition (preserving lean mass) and improving cardiovascular fitness, outcomes that AOMs alone do not fully address.

With that process substantially empowered by AOMs, lifestyle behavioral therapy could be refocused as a tool to optimize nutrition and physical activity in an attempt to improve overall health during weight loss. For example, higher protein intake with lifestyle-based treatment is associated with improved body composition during active weight loss and could be applicable during AOM use to optimize loss of fat mass with preservation of lean mass [15], or, while a patient is comfortably losing weight with an AOM, this could free up time to focus energy on improving cardiovascular fitness with increased levels of exercise.