Research
Energy balance
Achieving a total body weight loss of 10% or more in individuals with type 2 diabetes leads to progressive improvements in glycemic control and cardiometabolic risk factors, and may be necessary to reduce mortality.
If you have type 2 diabetes, aiming for 10% or more weight loss can provide even greater benefits for your heart health and longevity than the standard 5% goal. This may require more intensive lifestyle changes or medical support, but the potential to reduce cardiovascular events and death makes it a worthwhile target for many patients.
GoodSupportsHIGH confidence
Progressive improvements in glycaemic control and cardiometabolic risk factors can occur when the total body weight loss increases to 10% or more. ... reduction in mortality may require more than 10% total body WL.
Why this rating
Based on review of multiple studies and guidelines.
Source
Examining the evidence for weight management in individuals with type 2 diabetes
W. Timothy Garvey et al. · Diabetes Obesity and Metabolism · 2022
DOI 10.1111/dom.14764
narrative_reviewCited 17×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Achieving a total body weight loss of 5% or higher in individuals with type 2 diabetes and obesity significantly improves glycemic control (reducing HbA1c) and reduces the utilization of glucose-lowering medications.Good
- Bariatric surgery results in greater weight loss and higher rates of type 2 diabetes remission compared to sleeve gastrectomy, and is associated with reduced nephropathy and major adverse cardiovascular events.Moderate
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
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