Hormonal
High body mass index (BMI) and visceral adiposity are strong, independent risk factors for the development and progression of chronic kidney disease (CKD), end-stage renal disease (ESRD), and obesity-related glomerulopathy (ORG).
Maintaining a healthy weight is critical for kidney health. High BMI and visceral fat directly damage kidneys through increased pressure and hormonal imbalances, leading to chronic kidney disease. While weight loss in advanced kidney disease is complex, preventing obesity is the most effective way to protect your kidneys from long-term damage.
A high body mass index is one of the strongest risk factors for new-onset CKD... The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing CKD in the long-term. The incidence of obesity-related glomerulopathy has increased ten-fold in recent years.
Why this rating
Based on numerous population-based studies, large cohort analyses, and meta-analyses cited in the review.
Source
Obesity and kidney disease: hidden consequences of the epidemic
Csaba P. Kövesdy et al. · Brazilian Journal of Medical and Biological Research · 2017
DOI 10.1590/1414-431x20166075
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- Obesity increases the risk of nephrolithiasis (kidney stones) through mechanisms including lower urine pH, increased urinary oxalate, uric acid, sodium, and phosphate excretion, and insulin resistance.Good
- Obesity is associated with a significantly increased risk of kidney cancer, with a 5 kg/m2 higher BMI associated with a 25% higher risk of kidney cancers.Good
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