Research
Hormonal
Obesity increases the risk of nephrolithiasis (kidney stones) through mechanisms including lower urine pH, increased urinary oxalate, uric acid, sodium, and phosphate excretion, and insulin resistance.
Obesity increases your risk of kidney stones by changing your urine chemistry, making it more acidic and increasing stone-forming minerals. Maintaining a healthy weight can help reduce this risk.
GoodSupportsHIGH confidence
Obesity is associated with a number of risk factors contributing to the higher incidence and prevalence of nephrolithiasis. Higher body weight is associated with lower urine pH and increased urinary oxalate, uric acid, sodium and phosphate excretion... The insulin resistance characteristic of obesity may also predispose to nephrolithiasis...
Why this rating
Based on population-based studies and cohort analyses.
Source
Obesity and kidney disease: hidden consequences of the epidemic
Csaba P. Kövesdy et al. · Brazilian Journal of Medical and Biological Research · 2017
DOI 10.1590/1414-431x20166075
narrative_reviewCited 17×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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