Research
Energy balance
Obesity is caused by the interaction of genetic factors with an obesogenic environment (constant access to energy-dense food and minimal physical demands), termed a 'pathoenvironment' or 'obesigenic environment'.
You are living in an environment designed to make you gain weight. This is not your fault alone. Successful weight management requires recognizing this 'pathoenvironment' and actively creating counter-environments (e.g., restricting access to calorie-dense foods, increasing physical demands).
StrongSupportsVERY_HIGH confidence
In most cases inherited metabolic characteristics, combined with unfavourable environmental conditions such as constant access to energy-dense food and minimal physical demands of daily living, cause the development of obesity.
Why this rating
Supported by migration studies showing environmental impact and twin studies showing genetic susceptibility.
Source
Energy balance and weight regulation: genetics versus environment
Éric Ravussin et al. · British Journal Of Nutrition · 2000
DOI 10.1017/s0007114500000908
narrative_reviewCited 163×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Approximately two-thirds of the variability in Body Mass Index (BMI) among individuals within the same population is attributable to genetic factors rather than environmental differences.Good
- Genetic factors account for specific portions of BMI variability through three measurable metabolic traits: metabolic rate (12%), respiratory quotient/fat oxidation (5%), and spontaneous physical activity (10%), leaving 40% attributable to food intake regulation.Good
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