Mixed
Obese individuals with a normal metabolic profile (MHO) have significantly higher risks of heart failure, respiratory diseases, and all-cause mortality compared to non-obese individuals with a normal metabolic profile.
If you have obesity, do not assume you are 'healthy' just because your blood pressure and sugars are normal. You still face higher risks of heart failure and lung disease than someone who is not obese. Weight management is recommended for all people with obesity, regardless of their current metabolic profile, to lower these risks.
Compared with people who were metabolically healthy without obesity, participants with MHO had higher rates of incident diabetes (HR 4.32; 95% CI 3.83, 4.89), ASCVD (HR 1.18; 95% CI 1.10, 1.27), HF (HR 1.76; 95% CI 1.61, 1.92), respiratory diseases (HR 1.28; 95% CI 1.24, 1.33) and all-cause mortality (HR 1.22; 95% CI 1.14, 1.31).
Why this rating
Large prospective cohort (N=381,363), long follow-up (median 11.2 years), rigorous adjustment for confounders.
Source
Are people with metabolically healthy obesity really healthy? A prospective cohort study of 381,363 UK Biobank participants
Ziyi Zhou et al. · Diabetologia · 2021
DOI 10.1007/s00125-021-05484-6
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →