Mixed
Obese individuals with a normal metabolic profile (MHO) have significantly higher risks of heart failure, respiratory diseases, and all-cause mortality compared to non-obese individuals with a normal metabolic profile.
If you have obesity, do not assume you are 'healthy' just because your blood pressure and sugars are normal. You still face higher risks of heart failure and lung disease than someone who is not obese. Weight management is recommended for all people with obesity, regardless of their current metabolic profile, to lower these risks.
Compared with people who were metabolically healthy without obesity, participants with MHO had higher rates of incident diabetes (HR 4.32; 95% CI 3.83, 4.89), ASCVD (HR 1.18; 95% CI 1.10, 1.27), HF (HR 1.76; 95% CI 1.61, 1.92), respiratory diseases (HR 1.28; 95% CI 1.24, 1.33) and all-cause mortality (HR 1.22; 95% CI 1.14, 1.31).
Why this rating
Large prospective cohort (N=381,363), long follow-up (median 11.2 years), rigorous adjustment for confounders.
Source
Are people with metabolically healthy obesity really healthy? A prospective cohort study of 381,363 UK Biobank participants
Ziyi Zhou et al. · Diabetologia · 2021
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