Hormonal
GLP-1 receptor agonists (GLP-1RAs) significantly reduce hepatic steatosis and improve metabolic markers in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), but they do not significantly improve liver fibrosis.
GLP-1 medications like semaglutide and tirzepatide are effective at reducing liver fat and improving metabolic health in people with fatty liver disease. However, they do not currently appear to reverse liver scarring (fibrosis). While they offer significant benefits for steatosis and weight loss, patients should be aware of common gastrointestinal side effects and the current limitation regarding fibrosis reversal.
GLP-1RAs demonstrated significant improvement in LFC as evaluated by MRS or MRI-PDFF compared to placebo or active control in 6 trials... semaglutide significantly improved MASH without worsening fibrosis but did not improve fibrosis.
Why this rating
Based on multiple phase II RCTs and MRI-PDFF/MRS data, though fibrosis results were negative.
Source
Role of incretins and glucagon receptor agonists in metabolic dysfunction-associated steatotic liver disease: Opportunities and challenges
Chencheng Xie et al. · World Journal of Hepatology · 2024
DOI 10.4254/wjh.v16.i5.731
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