Energy balance
Significant weight loss (approx. 15% body weight) via once-weekly subcutaneous injections (e.g., semaglutide, tirzepatide) or bariatric surgery is an achievable and effective option for reducing CVD risk and improving glycemia in patients with RA or PsA, although evidence for disease activity improvement is mixed.
For RA/PsA patients with obesity, significant weight loss (~15%) via weekly GLP-1/GIP injections or bariatric surgery can improve glycemia and reduce CVD risk. However, evidence that this weight loss improves joint disease activity is mixed. Discuss these options with your doctor, considering cost and access.
new and emerging therapies have been shown to result in significant weight loss of around 15% body weight, that is sustained with once a week subcutaneous injections... bariatric surgery is often linked to significant and sustained weight loss and improvement in glycemia.
Why this rating
Based on studies in non-RA/PsA populations for efficacy, and mixed/limited studies specifically in RA/PsA for disease activity.
Source
Metabolic syndrome, rheumatoid and psoriatic arthritis: Managing cardiovascular risk
Milan K. Piya · International Journal of Rheumatic Diseases · 2021
DOI 10.1111/1756-185x.14197
More from this paper
- EULAR guidelines recommend early and aggressive screening and management of traditional cardiovascular disease (CVD) risk factors and metabolic syndrome components for all patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA).Moderate
- Chronic inflammation in RA and PsA contributes to increased CVD risk, but the prevalence of Metabolic Syndrome (MetS) alone may not fully account for this risk, particularly in RA where MetS prevalence is similar to the general population.Moderate
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
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