Hormonal
Daily administration of 100 mg mirabegron (a selective β3-AR agonist) increases energy expenditure and skin temperature in humans without cardiovascular side effects, offering a pharmacological alternative to cold exposure for activating brown adipose tissue.
If you are looking to boost metabolic rate through medication, 100 mg of mirabegron daily has been shown in studies to increase energy expenditure and skin temperature without causing heart issues. This is a repurposed drug originally for bladder issues, but it targets fat-burning pathways. Note that higher doses (150-200mg) may cause heart rate and blood pressure increases, so 100mg is the identified safe effective dose in the cited research.
one study that explored an effective and safe dosage for individual use revealed that a 100 mg daily intake increased the skin temperature and energy expenditure in participants without any cardiovascular side effects, while increased blood pressure and heart rate were observed at 150 and 200 mg doses, respectively [39].
Why this rating
The evidence is based on a single human study cited in a review; the review notes that most other drugs are only proven in mice.
Source
Thermogenic Fat as a New Obesity Management Tool: From Pharmaceutical Reagents to Cell Therapies
Ying Cheng et al. · Biomedicines · 2024
DOI 10.3390/biomedicines12071474
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