Hormonal
Activation of brown and beige adipose tissue through pharmacological means (e.g., β3-AR agonists, GLP-1RAs) or transplantation improves glucose metabolism, insulin sensitivity, and energy expenditure, offering a therapeutic strategy for obesity and type 2 diabetes.
Your body has a biological mechanism to burn extra energy as heat using brown and beige fat. While cold exposure and exercise can activate this, pharmaceutical approaches (like mirabegron or GLP-1 agonists) are being studied to enhance this process. This suggests that metabolic health is not just about calories in/out but also about the activity of specific fat tissues.
activation of brown/beige adipocytes by cold stimulation ameliorated glucose metabolism and insulin sensitivity in both healthy subjects and patients with T2DM... transplantation studies have demonstrated the essential role of BAT in improving adiposity, glucose metabolism, and insulin resistance in mice
Why this rating
Supported by multiple animal studies, some human clinical data, and mechanistic explanations.
Source
Thermogenic Fat as a New Obesity Management Tool: From Pharmaceutical Reagents to Cell Therapies
Ying Cheng et al. · Biomedicines · 2024
DOI 10.3390/biomedicines12071474
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