Research
Micronutrients & recovery
Vitamin E supplementation (800 IU daily) improves steatohepatitis, hepatic steatosis, and inflammation in adults with MASH who do not have diabetes, but does not improve fibrosis.
If you have MASH and do not have diabetes, your doctor may recommend 800 IU of Vitamin E daily. This dose has been shown to reduce liver inflammation and fat over 96 weeks, though it does not reverse scarring (fibrosis).
GoodQualifiesHIGH confidence
treatment with vitamin E 800 IU daily for 96 weeks was associated with significantly greater improvement in steatohepatitis, reduction in hepatic steatosis, reduced lobular inflammation, and reduced aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels compared to placebo. Despite these findings, vitamin E treatment did not improve fibrosis (98).
Why this rating
Based on a large multicenter, placebo-controlled trial (PIVENS) cited in the review.
Source
At the Crossroads of Health and Disease: Consequences of Fat in the Liver
Matthew Dukewich et al. · Annual Review of Physiology · 2025
narrative_reviewCited 11×
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