Mixed
Personalized nutrition interventions yield significantly greater reductions in body weight, BMI, waist circumference, and LDL cholesterol in individuals carrying the FTO risk genotype (TT/TC) compared to those with the non-risk genotype (CC).
If you carry the FTO risk genotype (TT or TC), a personalized nutrition plan is likely to be significantly more effective for weight and lipid management than a standard one-size-fits-all approach. You should prioritize interventions that are tailored to your specific metabolic profile, as your body appears to respond more robustly to dietary changes in this genetic context.
Generalized linear regression models showed that the reduction in weight, body mass index (BMI), WC, body fat percentage, total cholesterol (TCHO), and low-density lipoprotein (LDL) was greater in subjects with the risk genotype of FTO and in the PN group.
Why this rating
Randomized Controlled Trial (RCT) with a large sample size (N=400, 318 completers) and stratified analysis, though the TT subgroup was small (N=5).
Source
Gut microbiota modulates differential lipid metabolism outcomes associated with FTO gene polymorphisms in response to personalized nutrition intervention
Jianheng Zheng et al. · Frontiers in Nutrition · 2022
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