Macro partitioning
Isocalorically substituting 5% of total energy intake from Saturated Fatty Acids (SFA) and Trans-Fatty Acids (TFA) with Polyunsaturated Fatty Acids (PUFA) or Plant-based Monounsaturated Fatty Acids (MUFA) is associated with a statistically significant reduction in all-cause mortality risk.
To potentially lower your risk of all-cause mortality, focus on swapping the energy from Saturated Fats (SFA) and Trans Fats (TFA) for healthier fats. Specifically, aim to replace 5% of your total daily energy from SFA/TFA with Polyunsaturated Fats (PUFA, found in nuts, seeds, fish) or Plant-based Monounsaturated Fats (MUFA, found in olive oil). This swap is associated with a lower risk of death, according to a large network meta-analysis of observational studies.
Moderate CoE was found for an association with lower mortality risk when replacing 5% of energy from saturated fatty acids (SFA) and trans-fatty acids (TFA), with PUFA, MUFA, and plant-MUFA (HRrange: 0.75 to 0.91).
Why this rating
The certainty of evidence is rated as 'moderate' by the authors using the GRADE approach, downgraded due to risk of bias in observational studies.
Source
Association between substituting macronutrients and all-cause mortality: a network meta-analysis of prospective observational studies
Sabina Wallerer et al. · EClinicalMedicine · 2024
DOI 10.1016/j.eclinm.2024.102807
More from this paper
- Isocalorically substituting 5% of total energy intake from carbohydrates with polyunsaturated fatty acids (PUFA), specifically n-3 and n-6, or plant-based monounsaturated fatty acids (MUFA) is associated with a statistically significant reduction in all-cause mortality risk.Moderate
- Isocalorically substituting 5% of total energy intake from Animal Protein with Plant Protein is associated with a statistically significant reduction in all-cause mortality risk.Moderate
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