Adherence
Intensive lifestyle intervention (ILI) involving weight loss and increased physical activity does not reduce the rate of major cardiovascular events in adults with type 2 diabetes and a history of cardiovascular disease, and may be associated with a higher incidence of nonfatal myocardial infarction compared to diabetes support and education.
If you have type 2 diabetes and a history of heart disease, intensive lifestyle changes focusing on heavy weight loss and high-volume exercise may not protect your heart and could potentially increase the risk of a non-fatal heart attack compared to standard education. Consult your doctor before starting intense exercise programs to ensure they are safe for your specific cardiac condition.
Among participants with a history of CVD, the ILI group had a nonsignificantly higher incidence of the primary CVD outcome compared with the DSE group... Significant interaction P values were present for MI (P = 0.043), specifically nonfatal MI (P = 0.035)... The effect was due to higher rates of nonfatal MI in the ILI group, which contained a physical activity component, among those with baseline CVD.
Why this rating
Post-hoc exploratory analysis of a large RCT; interaction was nominally significant but not pre-specified as the primary endpoint for this subgroup.
Source
History of Cardiovascular Disease, Intensive Lifestyle Intervention, and Cardiovascular Outcomes in the Look AHEAD Trial
Cora E. Lewis et al. · Obesity · 2020
DOI 10.1002/oby.22676
Related findings · Adherence
- Regular physical activity (at least 150 minutes/week of moderate-intensity) reduces all-cause and cardiovascular mortality by 20-30% and lowers the risk of type 2 diabetes by 25-35%.Strong
- Increasing physical activity from a sedentary lifestyle to an active one in middle adulthood significantly reduces the risk of coronary events compared to remaining sedentary.Strong
- Resistance exercise is the only intervention capable of consistently restoring muscle function and strength in sarcopenia, partially overcoming age-related anabolic resistance.Strong
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