Research
Hormonal
Semaglutide, despite achieving NASH resolution, failed to improve fibrosis stage in phase 2 trials, highlighting a gap in treating advanced fibrosis compared to resmetirom.
Semaglutide helps resolve NASH but does not improve fibrosis. Patients with advanced fibrosis should consider other options like resmetirom.
GoodRefutesHIGH confidence
In the phase 2b study, semaglutide at the daily dose of 0.1, 0.2 and 0.4 mg significantly achieved NASH resolution compared with placebo, but failed to improve the fibrosis stage, irrespective of treatment dose.
Why this rating
Based on phase 2 RCT data.
Source
Breakthrough in the Treatment of Metabolic Associated Steatotic Liver Disease: Is it all over?
Maria Letizia Petroni et al. · Digestive and Liver Disease · 2024
DOI 10.1016/j.dld.2024.04.021
narrative_reviewCited 9×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Resmetirom is the first FDA-approved drug for treating noncirrhotic nonalcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis, demonstrating efficacy in resolving NASH without worsening fibrosis and improving fibrosis by at least one stage without worsening NASH.Strong
- Obeticholic acid (OCA) trials for NASH were discontinued due to safety concerns and modest efficacy, despite showing some histological improvement.Good
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