Research
Hormonal
Obeticholic acid (OCA) trials for NASH were discontinued due to safety concerns and modest efficacy, despite showing some histological improvement.
Obeticholic acid is not approved for NASH due to safety issues.
GoodRefutesHIGH confidence
Accordingly, the company decided to discontinue the NASH-related trial.
Why this rating
Based on phase 2 and 3 trial data.
Source
Breakthrough in the Treatment of Metabolic Associated Steatotic Liver Disease: Is it all over?
Maria Letizia Petroni et al. · Digestive and Liver Disease · 2024
DOI 10.1016/j.dld.2024.04.021
narrative_reviewCited 9×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Resmetirom is the first FDA-approved drug for treating noncirrhotic nonalcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis, demonstrating efficacy in resolving NASH without worsening fibrosis and improving fibrosis by at least one stage without worsening NASH.Strong
- Semaglutide, despite achieving NASH resolution, failed to improve fibrosis stage in phase 2 trials, highlighting a gap in treating advanced fibrosis compared to resmetirom.Good
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