Research
Hormonal
Lorcaserin IR and XR promote weight loss and improve glycemic control in overweight or obese patients with type 2 diabetes when used as an adjunct to lifestyle modifications.
If you have type 2 diabetes and are overweight, lorcaserin (10 mg once or twice daily) can help you lose weight and lower your HbA1c. It works best when combined with diet and exercise. Common side effects like headaches are usually mild.
GoodSupportsHIGH confidence
The decrease in HgBA1c was significantly different for both doses of lorcaserin IR compared to placebo (lorcaserin twice daily 0.9±0.06, lorcaserin once daily 1.0±0.09, placebo 0.4±0.06; P < 0.001).
Why this rating
Based on Phase III trials (BLOOM-DM).
Source
Challenging obesity, diabetes, and addiction: the potential of lorcaserin extended release
Ryan T. Hurt et al. · Diabetes Metabolic Syndrome and Obesity · 2018
DOI 10.2147/dmso.s126855
narrative_reviewCited 9×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Lorcaserin extended release (XR) 20 mg once daily is bioequivalent to lorcaserin immediate release (IR) 10 mg twice daily in terms of total exposure (AUC), offering a convenience advantage with potentially lower peak concentrations (Cmax).Good
- Lorcaserin IR (twice daily) improves smoking cessation rates and prevents post-cessation weight gain in overweight or obese smokers compared to placebo.Moderate
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