Research
Hormonal
Lorcaserin IR (twice daily) improves smoking cessation rates and prevents post-cessation weight gain in overweight or obese smokers compared to placebo.
If you smoke and are overweight, lorcaserin (10 mg twice daily) can help you quit smoking and prevent the weight gain that often follows. It works by reducing cravings and managing weight. This use is not FDA-approved, so discuss risks and benefits with your doctor.
ModerateSupportsMEDIUM confidence
The odds ratio (OR) for the twice a day lorcaserin versus placebo was 3.02 (95% CI, 1.47, 6.22, P = 0.003).
Why this rating
Based on a single large RCT, but no FDA approval for this indication.
Source
Challenging obesity, diabetes, and addiction: the potential of lorcaserin extended release
Ryan T. Hurt et al. · Diabetes Metabolic Syndrome and Obesity · 2018
DOI 10.2147/dmso.s126855
narrative_reviewCited 9×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Lorcaserin extended release (XR) 20 mg once daily is bioequivalent to lorcaserin immediate release (IR) 10 mg twice daily in terms of total exposure (AUC), offering a convenience advantage with potentially lower peak concentrations (Cmax).Good
- Lorcaserin IR and XR promote weight loss and improve glycemic control in overweight or obese patients with type 2 diabetes when used as an adjunct to lifestyle modifications.Good
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