Research

Micronutrients & recovery

Deuterated water (D2O) ingestion is a valid and increasingly used method for measuring long-term muscle protein synthesis in humans, providing insights that complement acute tracer infusion methods.

For researchers, D2O is a reliable tool for measuring long-term muscle protein synthesis. For practitioners, this validates that consistent, long-term training and nutrition strategies are what drive muscle changes, rather than just acute post-workout spikes.

GoodSupportsHIGH confidence
the resurgence of deuterated water (D2O) have enhanced our understanding of human skeletal muscle protein turnover (proteostasis)... The D2O approach permits measurements of muscle protein synthesis (MPS) over days, weeks or even months
Changhyun Lim et al. · Experimental Physiology · 2025

Why this rating

Supported by the authors' extensive use of the method and citations of prior studies.

Source

Turning over new ideas in human skeletal muscle proteostasis: What do we know and where to from here?

Changhyun Lim et al. · Experimental Physiology · 2025

narrative_reviewCited 8×
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