Hormonal
Activation of Glucagon-Like Peptide-1 Receptors (GLP-1R) in the Gustatory Cortex (GC) reduces homeostatic food intake in mice.
This research identifies a specific brain region (Gustatory Cortex) where GLP-1 receptors are active and influence how much we eat. While this doesn't change current dietary advice, it explains part of the mechanism behind GLP-1 based weight loss drugs, suggesting they work by altering how the brain processes taste and hunger signals, not just by signaling fullness from the gut.
Next we found that chemogenetic stimulation of GLP-1R1 neurons, and also pharmacological stimulation of GC-GLP-1Rs themselves, both reduced homeostatic food intake.
Why this rating
High-quality preclinical evidence using multiple methods (electrophysiology, chemogenetics, pharmacology) in controlled mouse models, though not directly translatable to humans without further study.
Source
Glucagon-Like Peptide-1 Receptors in the Gustatory Cortex Influence Food Intake
Amanda M. Dossat et al. · Journal of Neuroscience · 2023
DOI 10.1523/jneurosci.1668-22.2023
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