Research
Hormonal
The effect of GC GLP-1R activation on food intake is conditional on the palatability and fat content of the food, particularly in mice chronically maintained on a high-fat diet.
If you are trying to lose weight, switching from a high-fat diet to a lower-fat diet might make appetite-suppressing medications (like GLP-1 agonists) more effective. The brain's response to these drugs seems to depend on the palatability of the food, and changing your diet may help reset these signals.
GoodConditionalHIGH confidence
When mice were chronically maintained on diets with specific fat contents and then later offered foods with new fat contents, we also found that GLP-1R agonism reduced food intake toward foods with differing fat contents, indicating that GC GLP-1 influences may depend on palatability of the food.
Why this rating
Robust experimental design showing interaction between diet history and drug effect, but still in mice.
Source
Glucagon-Like Peptide-1 Receptors in the Gustatory Cortex Influence Food Intake
Amanda M. Dossat et al. · Journal of Neuroscience · 2023
DOI 10.1523/jneurosci.1668-22.2023
mechanism_only · n=51Cited 8×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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