Energy balance
Diet and lifestyle interventions reduce waist circumference regardless of TCF7L2 genotype, though the genotype does not modify this specific outcome.
You do not need to worry about your TCF7L2 genotype when it comes to losing belly fat. Standard diet and lifestyle changes will reduce waist circumference for everyone, regardless of whether you carry the risk allele. Focus on sustainable energy balance and activity.
Furthermore, regardless of genetic risk, diet/lifestyle interventions were associated with lower waist circumference.
Why this rating
Large sample size (n=4,114) and consistent direction of effect across studies, though heterogeneity was present.
Source
Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide
Tao Huang et al. · Health Data Science · 2021
DOI 10.34133/2021/9897048
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