Hormonal
Intensive lifestyle intervention (diet and exercise) does not significantly alter the rate of kidney function decline (eGFR slope) over 10 years in patients with type 2 diabetes and preserved baseline kidney function compared to usual care.
If you have type 2 diabetes and normal kidney function, an intensive lifestyle program focusing on weight loss and 175 minutes of weekly exercise will not significantly change the *rate* at which your kidney function declines over 10 years compared to standard diabetes care. However, it may help maintain a slightly higher average kidney function level, especially if your baseline function is already slightly reduced (eGFR <80). Focus on the overall health benefits rather than expecting a specific kidney outcome.
Over 10 years, there was no difference in eGFR slope (+0.064 per year; 95% CI: –0.036 to 0.16; P = 0.21) between arms. Slope or mean UACR did not differ between arms.
Why this rating
Post-hoc analysis of a large, long-term RCT (Look AHEAD) with rigorous statistical modeling, though limited by the use of creatinine-based eGFR which can be confounded by muscle loss.
Source
The 10-Year Effects of Intensive Lifestyle Intervention on Kidney Outcomes
Linda-Marie U. Lavenburg et al. · Kidney Medicine · 2024
DOI 10.1016/j.xkme.2024.100814
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