Hormonal
In patients with type 2 diabetes and baseline eGFR <80 mL/min/1.73 m2, intensive lifestyle intervention is associated with a slightly higher mean eGFR over 10 years compared to usual care, suggesting a potential benefit in preserving kidney function in this subgroup.
If your kidney function is already slightly reduced (eGFR <80), an intensive lifestyle program may help you maintain a slightly higher average kidney function level over 10 years compared to standard care. While it may not stop the decline entirely, it might offer a small protective benefit. Discuss this with your doctor to see if you are a candidate.
Among participants with baseline eGFR <80, lifestyle intervention had a slightly higher longitudinal mean eGFR than usual care.
Why this rating
Post-hoc subgroup analysis of a large RCT. The effect was statistically significant for mean eGFR but not slope, and the clinical significance is modest.
Source
The 10-Year Effects of Intensive Lifestyle Intervention on Kidney Outcomes
Linda-Marie U. Lavenburg et al. · Kidney Medicine · 2024
DOI 10.1016/j.xkme.2024.100814
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