Mixed
Dietary restriction (including caloric restriction, intermittent fasting, and ketogenic diets) extends healthspan and lifespan by promoting the clearance of senescent cells (senolysis), metabolic reprogramming, and epigenetic rejuvenation.
To leverage dietary restriction for longevity, you can adopt strategies like caloric restriction (eating less without being malnourished), intermittent fasting (eating within specific windows like 16:8), or ketogenic diets (high fat, low carb). These regimens aim to trigger biological processes like clearing out old cells (senolysis) and improving metabolic health, which may extend your healthspan. Start with small changes, like a shorter eating window, and ensure your diet remains nutrient-dense.
There is increasing evidence that dietary restriction (DR), including caloric restriction, fasting, or fasting-mimicking diets, extend both lifespan and healthspan. Here, we review the current evidence on the molecular mechanisms underlying DR-induced health improvements, including removal of senescent cells, metabolic reprogramming, and epigenetic rejuvenation.
Why this rating
The paper is a comprehensive review citing numerous preclinical (mouse, rat, yeast) and clinical (human) studies, though it acknowledges that causality in humans is still being established.
Source
Dietary restriction in senolysis and prevention and treatment of disease
Sepideh Aminzadeh-Gohari et al. · Critical Reviews in Food Science and Nutrition · 2022
DOI 10.1080/10408398.2022.2153355
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