Research
Micronutrients & recovery
The ratio of serum creatinine to cystatin C (Sarcopenia Index, SI) is a valid, non-invasive biomarker for estimating skeletal muscle mass and predicting mortality in sarcopenic populations, including those treated with GLP-1RA.
Ask your doctor about using a Sarcopenia Index (SI), calculated from your routine creatinine and cystatin C blood tests, to monitor your muscle health while on weight-loss medications. This simple calculation can help detect muscle loss early.
GoodSupportsHIGH confidence
The ratio of serum creatinine to cystatin C has been referred to as the sarcopenia index (SI). In a study of more than 450 000 UK Biobank participants, those with sarcopenia based on low maximum handgrip strength or reduction in muscle mass assessed using bioelectrical impedance had a 5%–10% lower SI...
Why this rating
Based on large cohort studies (UK Biobank, NHANES) and meta-analyses.
Source
Monitoring Sarcopenia With Incretin Receptor Activator Treatment
Zachary T. Bloomgarden · Journal of Diabetes · 2025
DOI 10.1111/1753-0407.70117
narrative_reviewCited 4×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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