Research
Hormonal
Discontinuation of obesity medications leads to weight regain and reversal of cardiometabolic improvements, necessitating long-term treatment.
If you are taking obesity medications, you likely need to continue them long-term to maintain weight loss. Stopping the medication often leads to weight regain. Talk to your doctor about managing costs and side effects to stay on treatment.
StrongSupportsHIGH confidence
Obesity medications do not permanently alter the underlying neuroendocrine disruption associated with obesity, meaning that medications and lifestyle modifications should be continued long-term to promote weight maintenance...
Why this rating
Based on withdrawal trials (SURMOUNT 4, STEP 4).
Source
Obesity: assessment and treatment across the care continuum
Robert F. Kushner et al. · Annals of Medicine · 2025
narrative_reviewCited 4×
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