Research
Mixed
Obesity is a chronic disease of dysregulated energy balance involving neuroendocrine factors, requiring lifelong, multimodal management (lifestyle, pharmacotherapy, surgery) tailored to individual patient characteristics and evolving goals.
Treat obesity as a chronic disease requiring long-term management. Work with your healthcare provider to create a personalized plan involving lifestyle changes, medications, or surgery based on your specific health needs and goals. Regular follow-up is essential to adjust treatment as your needs change.
StrongSupportsHIGH confidence
Obesity is a chronic condition of dysregulated energy balance that is caused by a confluence of nutritional, neurological, hormonal and metabolic factors... Treatment should be based on a shared decision-making process... that can include a combination of behavioural and lifestyle interventions, pharmacological therapies and surgery.
Why this rating
Narrative review of broad literature with consensus guidelines.
Source
Obesity: assessment and treatment across the care continuum
Robert F. Kushner et al. · Annals of Medicine · 2025
DOI 10.1080/07853890.2025.2521433
narrative_reviewCited 4×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Discontinuation of obesity medications leads to weight regain and reversal of cardiometabolic improvements, necessitating long-term treatment.Strong
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
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