Research
Hormonal
Caffeine ingestion of moderate to high doses enhances endurance exercise, strength, and peak power performance.
If you engage in endurance, strength, or peak power activities, moderate to high doses of caffeine can enhance performance. Be aware of potential side effects like nervousness or sleep disturbances.
ModerateSupportsMEDIUM confidence
With regard to endurance exercise, strength and peak power, the performance is enhanced after caffeine ingestion of moderate to high doses.
Why this rating
Review paper citing studies.
Source
Improvement of physical training by performance‐enhancing substances
Cem Erdoğan · Acta Physiologica · 2020
DOI 10.1111/apha.13517
narrative_reviewCited 4×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Protein supplementation combined with resistance exercise increases muscle mass and strength, but intakes above 1.6 g/kg body weight per day provide no additional significant gains.Good
- Creatine supplementation increases strength, performance in short-duration high-intensity exercises, and total force by increasing ATP availability and potentially enhancing satellite cell differentiation.Moderate
- Beta-hydroxy-beta-methylbutyrate (HMB) supplementation enhances protein synthesis, reduces protein breakdown, and increases muscle size, strength, and aerobic performance when combined with exercise.Moderate
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →