Research
Macro partitioning
Beta-hydroxy-beta-methylbutyrate (HMB) supplementation enhances protein synthesis, reduces protein breakdown, and increases muscle size, strength, and aerobic performance when combined with exercise.
If you exercise, HMB supplementation can enhance muscle size, strength, and aerobic performance. It does not work without exercise.
ModerateSupportsMEDIUM confidence
HMB enhances protein synthesis and reduces protein breakdown in skeletal muscles... HMB increases muscle size, strength, aerobic performance, regenerative capacity and reduces muscle damage.
Why this rating
Review paper citing studies.
Source
Improvement of physical training by performance‐enhancing substances
Cem Erdoğan · Acta Physiologica · 2020
DOI 10.1111/apha.13517
narrative_reviewCited 4×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
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- Creatine supplementation increases strength, performance in short-duration high-intensity exercises, and total force by increasing ATP availability and potentially enhancing satellite cell differentiation.Moderate
- Caffeine ingestion of moderate to high doses enhances endurance exercise, strength, and peak power performance.Moderate
Related findings · Macro partitioning
- Total daily protein intake of 1.6 g/kg/day is sufficient for maximizing resistance training-induced muscle gains, with an upper confidence interval of 2.2 g/kg/day.Strong
- Resistance exercise training combined with sufficient dietary protein intake acts synergistically to maximize skeletal muscle hypertrophy, with protein intake saturating around 1.6 g/kg/day for general populations and potentially requiring 2.0-2.2 g/kg/day for resistance-trained individuals.Strong
- Trans fats should be completely eliminated from the diet, as they increase LDL cholesterol, decrease HDL cholesterol, and are directly associated with increased coronary risk.Strong
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