Research
Adherence
Polygenic risk scores (PRS) and genetic risk scores (GRS) can identify individuals with high genetic susceptibility to obesity, allowing for targeted preventative interventions.
While PRS can identify high-risk individuals, current scores are not precise enough for individual clinical decision-making for most people. Focus on standard healthy lifestyle habits regardless of genetic testing results.
ModerateQualifiesMEDIUM confidence
PRSs, on the other hand, represent a more comprehensive approach, encompassing potentially thousands or even millions of common genetic variants identified through GWASs... These scores may help to target more intensive and personalized preventative interventions relating to diet and exercise
Why this rating
Narrative review of observational studies; predictive power at individual level is acknowledged as limited.
Source
Unraveling the Genetic Architecture of Obesity: A Path to Personalized Medicine
Faisal Kunnathodi et al. · Diagnostics · 2025
DOI 10.3390/diagnostics15121482
narrative_reviewCited 4×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Monogenic obesity caused by leptin deficiency can be effectively treated with recombinant leptin therapy, restoring normal appetite regulation.Good
- Genetic variants in the FTO gene increase obesity susceptibility, but this genetic risk can be reduced by approximately 30% through engagement in physical activity.Moderate
Related findings · Adherence
- Regular physical activity (at least 150 minutes/week of moderate-intensity) reduces all-cause and cardiovascular mortality by 20-30% and lowers the risk of type 2 diabetes by 25-35%.Strong
- Increasing physical activity from a sedentary lifestyle to an active one in middle adulthood significantly reduces the risk of coronary events compared to remaining sedentary.Strong
- Resistance exercise is the only intervention capable of consistently restoring muscle function and strength in sarcopenia, partially overcoming age-related anabolic resistance.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →