Research
Energy balance
Genetic variants in the FTO gene increase obesity susceptibility, but this genetic risk can be reduced by approximately 30% through engagement in physical activity.
If you have a family history of obesity, do not assume you are destined to gain weight. Research shows that regular physical activity can significantly blunt the impact of common obesity genes (like FTO). Prioritize consistent exercise as a primary tool to manage your genetic risk.
ModerateQualifiesMEDIUM confidence
Engaging in physical activity can reduce the effect of FTO SNPs on obesity susceptibility by approximately 30% [58]
Why this rating
The paper is a narrative review citing observational/epidemiological studies; it does not present new primary RCT data.
Source
Unraveling the Genetic Architecture of Obesity: A Path to Personalized Medicine
Faisal Kunnathodi et al. · Diagnostics · 2025
DOI 10.3390/diagnostics15121482
narrative_reviewCited 4×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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