Mixed
The interaction between physical activity levels and carbohydrate intake significantly influences blood glucose concentrations, with the magnitude and direction of this effect moderated by an individual's genetic risk score (GRS).
Your blood sugar response to eating carbs and exercising is not one-size-fits-all. It depends on your specific genetic makeup. While general advice holds, personalized adjustments based on your genetic risk score and activity level may be necessary for optimal glucose control.
Interestingly, an interaction affecting glycaemia, concerning physical activity level with carbohydrate intake, was found (β = −0.060, p = 0.033), which also significantly depended on the genetic background (GRS).
Why this rating
Observational baseline analysis from an RCT cohort; statistically significant but lacks causal intervention data on the interaction itself.
Source
Interactions of Carbohydrate Intake and Physical Activity with Regulatory Genes Affecting Glycaemia: A Food4Me Study Analysis
Santiago Navas‐Carretero et al. · Lifestyle Genomics · 2021
DOI 10.1159/000515068
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