Research
Mixed
The protective effect of higher carbohydrate intake on hypertension is mediated by improved psychological well-being and reduced adiposity.
Eating a diet with 42-51% of calories from carbohydrates may help lower blood pressure not just by weight management, but also by improving mental health and reducing stress-related factors like depression and anxiety.
GoodSupportsHIGH confidence
Higher relative carbohydrate intake was causally associated with lower hypertension risk, substantially mediated by better psychological well-being and less adiposity.
Why this rating
Two-step MR provides strong evidence for mediation, though it is still observational in nature.
Source
Causal Effect of Relative Carbohydrate Intake on Hypertension through Psychological Well-Being and Adiposity: A Mendelian Randomization Study
Chaojie Ye et al. · Nutrients · 2023
DOI 10.3390/nu15224817
cohortCited 4×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →